path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers")

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PubMed:26631930

In an analogy to the evolution of concepts in the ‘amyloid cascade hypothesis’, which proposes that soluble oligomers — rather than insoluble aggregates of amyloid peptides — are the causative agents of neurodegeneration in AD, recent studies have suggested tau oligomers to be the toxic species, and indeed levels of SDS-stable tau oligomers are increased in AD and PSP brains.

Related Edges 4

• a(HBP:"Tau oligomers") increases path(HBP:Neurodegeneration)
• a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease")
• a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
• path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")

MeSH

Brain

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