p(HGNC:NPEPPS) decreases path(MESH:Tauopathies)

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PubMed:24027553

In addition, a non-functional PSA mutant exacerbated tau pathology in a Drosophila model of tauopathy, while overexpressing PSA ameliorated the tau phenotype and diminished tau levels (10). Overexpressing PSA had a similar effect in the TAUP301L mice, reducing the pathologic phenotype (delaying paralysis, increasing motor neuron density in the spinal cord, decreasing gliosis) and decreasing tau levels (12).

Related Edges 4

• p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L"))
• p(HGNC:NPEPPS) decreases p(HGNC:MAPT)
• p(HGNC:NPEPPS) decreases path(MESH:Paralysis)
• p(HGNC:NPEPPS) decreases path(MESH:Gliosis)

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