act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7)

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PubMed:19293145

The nicotine-induced nAChR up-regulation in human SH-EP1 cells heterologously expressing alpha7 nAChRs is mediated by cAMP and protein kinase C (PKC) (Nuutinen et al., 2006). The effects of long-term nicotine treatment on nAChR expression in rat brain differs for receptors of different subtype composition (most pronounced up-regulation being observed for alpha4beta2 receptors) and for different brain regions (Nguyen et al., 2003).

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• composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine))

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