p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441")))

PubMed:26631930

In the human brain, tau can be cleaved behind Thr123, generating an N‑terminally truncated, tau124–441 fragment. This fragment exhibits stronger affinity for microtubules than does full-length tau, presumably because the removal of the negatively charged N‑terminal domain enhances its binding to the negative surface of microtubules

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