act(p(INTERPRO:"Heat shock protein Hsp90 family")) positiveCorrelation act(p(HGNC:HDAC6))

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PubMed:29844403

This study aimed to investigate the protective effects and mechanism of the novel HDAC6 inhibitor, MPT0G211, using an AD model. Our results indicated that MPT0G211 significantly reduced tau phosphorylation and aggregation, the processes highly correlated with the formation of NFTs. This HDAC6 inhibitory activity resulted in an increase in acetylated Hsp90, which decreased Hsp90 and HDAC6 binding, causing ubiquitination of phosphorylated tau proteins. In addition, a significant increase of phospho-glycogen synthase kinase-3β (phospho-GSK3β) on Ser9 (the inactive form) through Akt phosphorylation was associated with the inhibition of phospho-tau Ser396 in response to MPT0G211 treatment.

Related Edges 8

• a(HBP:MPT0G211) directlyDecreases act(p(HGNC:HDAC6))
• a(HBP:MPT0G211) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
• a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
• a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
• p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation act(p(HGNC:GSK3B))
• act(p(HGNC:GSK3B)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
• p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B))
• act(p(HGNC:HDAC6)) positiveCorrelation act(p(INTERPRO:"Heat shock protein Hsp90 family"))

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