a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") association a(HBP:"GVD bodies")

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PubMed:26501932

Pretangles contained either paired helical filaments (PHFs) or PtdIns(4,5)P2-immunopositive small vesicles (approximately 1 µm in diameter) with nearly identical topology to granulovacuolar degeneration (GVD) bodies. Various combinations of these vesicles and GVD bodies, the latter of which are pathological hallmarks observed within the neurons of AD patients, were found concurrently in neurons.These vesicles and GVD bodies were both immunopositive not only for PtdIns(4,5)P2, but also for several tau kinases such as glycogen synthase kinase-3ß and spleen tyrosine kinase.

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• a(HBP:"GVD bodies") association a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate")

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