a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))

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PubMed:17187063

These results are consistent with previous in vitro studies and indicate that tau induces actin-filament bundling in vitro and F-actin accumulation in vivo, most likely through a direct interaction with F-actin.For genetic analysis, we selected a line of tauV337M-expressing flies that has a moderate rough eye and is a good substrate for genetic modification. Coexpressing an actin transgene (UAS–Act5C–EGFP;GMR– GAL4 driver) markedly enhanced tauV337M-induced toxicity.

Related Edges 5

• complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
• p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin")
• p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
• complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration)
• p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration)

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