a(HBP:HBP00006) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons))

PubMed:26458742

Importantly, neuronal uptake of HMW tau occurred in vivo as well; human tau uptake in neurons was detected in young rTg4510 (pre-tangle stage) (Fig. 1j–l) and WT (Supplementary Fig. 6) mice injected with the HMW SEC fraction of Tg4510 (12 months) brain extract, but not in those injected with the LMW fractions.

Confidence

High

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