a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta"))

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PubMed:19293145

ApoE-epsilon4, but not ApoE-epsilon3, disrupts carbachol-stimulated phosphoinositol (PI) hydrolysis and so does Abeta and Abeta/ApoE-epsilon4 complexes in SH-SY5Y cells (Cedazo- Mínguez and Cowburn, 2001). The effect of Abeta and its ApoE complex on PI hydrolysis were blocked by estrogen, and this disruption was itself blocked by wortmannin, suggesting that PI3K mediates estrogen’s effect on PI hydrolysis.

Related Edges 6

• a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis))
• act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol)
• a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4"))
• a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen))
• p(FPLX:PI3K) regulates act(a(CHEBI:estrogen))
• p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis))

Experimental Factor Ontology (EFO)

SH-SY5Y

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