p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates")

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PubMed:26631930

Disruption of these motifs (for example, by Pro mutations) abrogates the tendency for tau to aggregate; by contrast, strengthening the β‑structure with certain mutations (for instance, ΔK280 or P301L) accelerates tau aggregation both in vitro and in vivo

Related Edges 3

• p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates")
• p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")

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