complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT))

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PubMed:10391244

To examine whether Pin1 affects the ability of pTau to bind microtubules, we generated pTau in vitro using purified Cdc2 (refs 17, 18), and determined its ability to bind Taxol-stabilized microtubules with or without Pin1. Although Cdc2 phosphorylation disrupted the ability of tau to bind microtubules; the binding was fully restored by preincubation with Pin1 (Fig. 5a). Furthermore, Pin1 was detected in the fraction of tau-bound microtubules (Fig. 5a). However, no Pin1 was detected in the microtubule fraction if pTau was not added (Fig. 5a), indicating that Pin1 does not bind microtubules directly. Thus, Pin1 binds pTau and restores its ability to bind microtubules.

Related Edges 2

• act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
• p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT))

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