path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR")

PubMed:19126755

In summary, while nicotine-induced upregulation requires at least the beta2 nAChR subunit, development of tolerance to nicotine requires neither the beta2 nor the alpha7 nAChR subunit; instead, it appears to be modulated by a beta4-containing nAChR and to require an alpha4-containing nAChR.

Related Edges 3

• a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance")
• p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance")
• path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4)

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