p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process")

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PubMed:22908190

That presenilin 1 mutations, which are a cause of early-onset familial AD, impede lysosome proteolysis and accelerate neuritic dystrophy also supports a primary role for failure of proteolytic clearance (Lee et al. 2010).

Related Edges 2

• p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease")
• p(HGNC:PSEN1, var("?")) decreases act(a(HBP:Neurites))

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