complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex"))

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PubMed:24561250

As for the NLRP1 and NLRP3 inflammasomes, the oligomerzied NLRs recruit and interact with the adaptor protein ASC, which in turn recruits the effector protein procaspase-1 that is central to the activation of inflammasomes (Huang et al., 2013)

Related Edges 1

• complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex"))

Confidence

High

NeuroMMSigDB

Caspase subgraph

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