act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration)

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PubMed:25514383

In a mouse model of AD, cotinine treatment decreased the plaque load and was able to activate the Akt pathway, that was shown to be neuroprotective (Echeverria et al., 2011)

Related Edges 2

• a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid")
• a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT))

MeSH

Alzheimer Disease

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