p(HGNC:HBB) positiveCorrelation path(HM:"endothelial lesions")

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PubMed:29929138

Endothelial injury may also be related to Free hemoglobin and its breakdown oxidative product heme, and MPs, which mediates direct proinflammatory, proliferative, and pro-oxidant effects on endothelial cells [22–24] both in PNH and congenital CD59 deficiency, but may be more pronounced in congenital CD59 deficiency and perhaps even more in the brain due to loss of CD59 in the endothelium of these patients.

Related Edges 5

• a(CHEBI:heme) positiveCorrelation path(HM:"endothelial lesions")
• a(MESH:"Cell-Derived Microparticles") positiveCorrelation path(HM:"endothelial lesions")
• path(HM:"endothelial lesions") positiveCorrelation p(HGNC:HBB)
• path(HM:"endothelial lesions") positiveCorrelation a(CHEBI:heme)
• path(HM:"endothelial lesions") positiveCorrelation a(MESH:"Cell-Derived Microparticles")

Cell Ontology (CL)

platelet

MeSH

Endothelium

MeSH

Hemoglobinuria, Paroxysmal

Text Location

Discussion

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