a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7, var("p.L250T")))

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PubMed:19293145

Although there is abundant evidence that Abeta can affect nAChR function, studies disagree as to whether Abeta is an antagonist or an agonist at nAChRs (these findings are summarized in Table 1). For example, Abeta has been reported to inhibit single-channel nicotinic receptor currents in rat hippocampal interneurons (Pettit et al., 2001) as well as currents recorded from human alpha7 receptors heterologously expressed in Xenopus laevis oocytes (Tozaki et al., 2002; Grassi et al., 2003; Pym et al., 2005). Abeta, however, activates a mutant (L250T) of the alpha7 receptor—this mutant conducts current in the desensitized state, indicating that Abeta may exert its antagonistic action through receptor desensitization (Grassi et al., 2003).

Related Edges 2

• a(CHEBI:"amyloid-beta") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
• act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta")

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