p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt))

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PubMed:29024336

Taken together, our in vitro and cell-based studies argue that these two point mutations, A152T and P301L, reduce the normal degradation of tau by CMA, although the P301L mutation has a more pronounced inhibitory effect

Related Edges 2

• bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt))
• p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt))

MeSH

Lysosomes

Confidence

High

MeSH

Brain

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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