a(CHEBI:Anatabine) decreases r(HGNC:BACE1)

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PubMed:26010758

Additionally, we found that Bace1 mRNA expression is significantly increased in the brain of Tg PS1/APPswe mice compared to wild- type littermates, whereas a significant reduction in Bace1 mRNA levels is observed in Tg PS1/ APPswe receiving 20 mg/Kg/Day of anatabine in their drinking water showing that at this dosage anatabine can mitigate the upregulation of Bace1 expression in Tg PS1/APPswe mice (Fig 9).

Related Edges 1

• a(CHEBI:"amyloid-beta") increases r(HGNC:BACE1)

MeSH

Brain

MeSH

Alzheimer Disease

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