act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity)

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PubMed:19293145

Genistein, a phytoestrogen, protects SH-SY5Y cells (Bang et al., 2004) as well as cultured hippocampal neurons (Zeng et al., 2004) from Abeta toxicity. However, in addition to its action on estrogen receptors, genistein is also a general tyrosine kinase inhibitor that protects cultured neurons from L-glutamate toxicity (Kajta et al., 2007).

Related Edges 3

• act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity)
• a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta"))
• a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)"))

Experimental Factor Ontology (EFO)

SH-SY5Y

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