p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))

PubMed:21214928

Manipulation of ADAM17 can alter alpha-cleavage of APP and Abeta generation, with regulated alpha-cleavage abolished in ADAM17-deficient cells, suggesting that ADAM17 is likely the alpha-secretase responsible for regulated APP cleavage [47]

Confidence

Medium

MeSH

Neurons

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