a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR"))

PubMed:19126755

The receptor that exhibits the greatest upregulation when exposed to nicotine is the alpha4beta2 nAChR. Receptors assembled from this subunit combination form the highaffinity nicotine binding site (151, 215) and account for the vast majority of upregulated sites in the brain of smokers (55).

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• a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR")

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