complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT))

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PubMed:19293145

In a microarray study comparing brains from patients with AD with control brains, FYN was found to be significantly upregulated in AD (Wang et al., 2003a). In this context, it is of interest that FYN has also been shown to activate the PI3K/AKT cascade, thereby inhibiting apoptosis (Tang et al., 2007). Indeed, FYN is required for phos- phorylation of phosphoinositide 3-kinase enhancer (PIKE), which itself regulates AKT (Fig. 3). PIKE binds to AKT and up-regulates its kinase a ctivity, thereby reducing apoptosis. Phosphorylation protects PIKE from caspase cleavage, hence FYN is antiapoptotic (Tang et al., 2007).

Related Edges 5

• p(HGNC:FYN) increases act(p(FPLX:PI3K))
• p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph))
• p(HGNC:FYN) decreases bp(GO:"apoptotic process")
• act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process")
• path(MESH:"Alzheimer Disease") increases p(HGNC:FYN)

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