p(MGI:Dnm1l) positiveCorrelation bp(GO:"mitochondrial fission")

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PubMed:28173111

Using real-time RT-PCR, immunoblotting and immunostaining analyses, we measured mRNA expressions and protein levels of genes related to the mitochondrial dynamics—Drp1 and Fis1 (fission), Mfn1, Mfn2 and Opa1 (fusion), CypD (matrix), mitochondrial biogenesis—Nrf1, Nrf2, PGC1a and TFAM and synaptic— synaptophysin, PSD95, synapsin 1, synaptobrevin 1, neurogranin, GAP43 and synaptopodin in brain tissues from 6-month old Drp1þ/+-, Tau, TauXDrp1þ/+- and wild-type mice. Decreased mRNA and protein levels of fission and matrix and increased levels of fusion, mitochondrial biogenesis, and synaptic genes were found in 6-month-old TauXDrp1þ/+- mice relative to Tau mice. Mitochondrial dysfunction was reduced in TauXDrp1þ/+- mice relative to Tau mice.

Related Edges 85

• bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Fis1)
• bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Dnm1l)
• bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn1)
• bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn2)
• bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Opa1)
• complex(GO:"mitochondrial matrix") positiveCorrelation p(MGI:Ppid)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syp)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Dlg4)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn1)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn2)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins")
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Synpo2)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Nrgn)
• act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Gap43)
• complex(GO:mitochondrion) positiveCorrelation p(MGI:Nrf1)
• complex(GO:mitochondrion) positiveCorrelation p(MGI:Nfe2l2)
• complex(GO:mitochondrion) positiveCorrelation p(MGI:Ppargc1a)
• p(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l)
• p(MGI:Fis1) positiveCorrelation bp(GO:"mitochondrial fission")
• p(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Mfn1) positiveCorrelation bp(GO:"mitochondrial fusion")
• p(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Mfn2) positiveCorrelation bp(GO:"mitochondrial fusion")
• p(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Nfe2l2) positiveCorrelation complex(GO:mitochondrion)
• p(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Nrf1) positiveCorrelation complex(GO:mitochondrion)
• p(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Opa1) positiveCorrelation bp(GO:"mitochondrial fusion")
• p(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l)
• p(MGI:Ppargc1a) positiveCorrelation complex(GO:mitochondrion)
• p(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l)
• p(MGI:Ppid) positiveCorrelation complex(GO:"mitochondrial matrix")
• p(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l)
• r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l)
• r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Dlg4) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn2)
• r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins")
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo2)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43)
• r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1)
• r(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1)
• r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid)
• r(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a)
• r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam)
• r(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam)
• r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l)
• r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Gap43) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Nrgn) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l)
• r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Syn1) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Syn2) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Syn2) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Synpo2) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Synpo2) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l)
• r(MGI:Syp) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
• r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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