tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome))

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PubMed:23702978

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated.

Related Edges 6

• complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1))
• complex(GO:"inflammasome complex") increases bp(GO:pyroptosis)
• complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11))
• act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9))
• act(p(HGNC:CASP1)) increases bp(GO:pyroptosis)
• act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis)

Confidence

Medium

NeuroMMSigDB

Apoptosis signaling subgraph

NeuroMMSigDB

Caspase subgraph

NeuroMMSigDB

XIAP subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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