Appears in Networks 1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Provenance

PubMed:12714745

Recent studies of an individual with Parkinson’s disease (IX-47) of the Contursi kindred with the rare A53T alpha-synuclein mutation revealed widespread -syn and tau inclusions (15). Post-mortem examination of another affected member (IX-51) of this kindred also demonstrated abundant -syn and tau inclusions(figs. S1 and S2). Thus, a pathogenic mutation in alpha-synuclein that is known to increase the propensity of alpha-synuclein to fibrillize (8, 9) also promotes formation of tau inclusions in humans.

Related Edges 3

Annotations 1

Disease Ontology (DO)
Parkinson's disease

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