a(CHEBI:bexarotene) increases act(p(FPLX:RXR))

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PubMed:21718217

Bexarotene is a highly specific RXR agonist and is currently FDA approved with a favorable side effect profile. Studies in our laboratory have shown that treatment of APP/ PS1 animals with bexarotene for only 3 days results in a dramatic induction of ApoE and ABCA1 and the rapid reversal of AD-associated pathological hallmarks including reduction in amyloid deposition and deficits in behavior as well as neural networks.

Related Edges 4

• a(CHEBI:bexarotene) increases p(HGNC:APOE)
• a(CHEBI:bexarotene) increases p(HGNC:ABCA1)
• a(CHEBI:bexarotene) decreases a(HBP:HBP00018)
• a(CHEBI:bexarotene) increases bp(GO:behavior)

Confidence

High

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