complex(a(MESH:"haptoglobin-hemoglobin complex"), p(HGNC:CD163)) increases bp(MESH:Endocytosis)
Once cell-free hemoglobin was bound by its scavenger haptoglobin, the resulting haptoglobin–hemoglobin complex will bind to CD163 on the surface of macrophages/monocytes to initiate endocytosis and degradation of the complex [12, 39].
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.