a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex"))

View Subject View Object

PubMed:25652642

Mechanistically, the Aβ induced neuronal apoptosis has been attributed to the increase in the ratio of proapoptotic gene (BAX) transcription to that of the anti-apoptotic gene Bcl-Xl, and/or to the reduction in constitutively activated NF-κB with consequent increase in the cytoplasmic IκB proteins

Related Edges 4

• a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
• a(CHEBI:"amyloid-beta") increases p(HGNC:BAX)
• a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1)
• a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins")

MeSH

Alzheimer Disease

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---