p(HGNC:MAPT) increases tloc(p(HGNC:APP), fromLoc(GO:cytoplasm), toLoc(GO:"cell surface"))

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PubMed:26631930

This study revealed that tau deficiency can cause iron accumulation inside neurons by preventing the trafficking of APP to the cell surface, where APP usually interacts with ferroportin (FPN) to facilitate the export of iron

Related Edges 3

• p(HGNC:MAPT) decreases a(CHEBI:"iron(0)")
• complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)"))
• surf(p(HGNC:APP)) increases complex(p(HGNC:APP), p(HGNC:SLC40A1))

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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