a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))

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PubMed:28391535

This conclusion is based on the fact that the stimulus effects of nicotine are convincingly blocked by (a) mecamylamine, a voltage dependent noncompetitive channel blocker at nicotinic receptors (Fig. 3; Table 4) and (b) dihydro-β-erythrodine (DHβE), a nicotinic receptor antagonist that shows high affinity for the nAChR α4β2 subunit (Fig. 3; Table 5) but not by methyllycaconitine (MLA), a α7 nicotinic receptor antagonist (Table 5).

Related Edges 5

• a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine))
• a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine))
• a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2"))
• a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic"))
• a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine))

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