complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA))

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PubMed:27796283

These observations suggest that CaMKv blocks RhoA activity by preventing its interaction with Lfc. These results demonstrate that CaMKv regulates spine maintenance through RhoA inhibition. The suppression of the Lfc/RhoA pathway by AMPA receptors is implicated in dendritic spine maintenance10. Given that CaMKv expression is upregulated by synaptic activity, CaMKv may be a key signalling protein that transduces the signals from AMPA receptors to suppress RhoA during activity-dependent spine maintenance. Corroborating this, the AMPA receptor blocker NBQX attenuated CaMKv expression in neurons (Fig. 3i,j). Importantly, CaMKv overexpression completely rescued NBQX-induced spine loss (Fig. 3k,l). These findings collectively reveal that activity-dependent CaMKv expression and the subsequent inhibition of Lfc/RhoA are required to mediate AMPA receptor function in spine maintenance.

Related Edges 4

• act(a(MESH:Neurons)) increases p(HGNC:CAMKV)
• act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA))
• act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA))
• act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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