a(CHEBI:heme) negativeCorrelation act(a(CHEBI:antioxidant))

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PubMed:25307023

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005).

Related Edges 12

• a(CHEBI:"iron(2+)") decreases act(a(CHEBI:antioxidant))
• a(CHEBI:"iron(2+)") increases path(MESH:Inflammation)
• a(CHEBI:"iron(2+)") decreases bp(MESH:Vasodilation)
• a(CHEBI:"iron(2+)") increases bp(GO:"cell proliferation")
• act(a(CHEBI:antioxidant)) negativeCorrelation a(CHEBI:heme)
• a(CHEBI:heme) increases bp(GO:"cell proliferation")
• a(CHEBI:heme) increases path(MESH:Inflammation)
• a(CHEBI:heme) decreases bp(MESH:Vasodilation)
• p(HGNC:HBB) decreases bp(MESH:Vasodilation)
• p(HGNC:HBB) increases bp(GO:"cell proliferation")
• p(HGNC:HBB) increases path(MESH:Inflammation)
• p(HGNC:HBB) decreases act(a(CHEBI:antioxidant))

Cell Ontology (CL)

macrophage

Text Location

Review

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