a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains))

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PubMed:24027553

Calpains are calcium-activated cytosolic cysteine proteases. Two isoforms differentiated and named by their sensitivities to calcium (i.e., μ-calpain and m-calpain, also called calpain-1 and calpain-2) are abundant in the central nervous system, and respond to micromolar and millimolar concentrations of calcium, respectively (45). Calpain has been implicated in a number of neurodegenerative diseases [for a review, see (46)].

Related Edges 2

• p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases")
• path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains)

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