p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")

View Subject View Object

PubMed:29758300

For example, in tau A152T iPSC-derived cortical neurons, total and phosphorylated Tau levels are elevated, particularly the insoluble forms [133], which is associated with decreases in UPS function as measured by total polyubiquitinated proteins and an upregulation of macroautophagy markers.

Related Edges 3

• p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
• p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy)
• p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr"))

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---