a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides)

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PubMed:19293145

Nicotine may regulate the neuroprotective secretion of TNFalpha by microglia through enhancement of lowlevel TNF secretion and suppression of lipopolysaccharide- induced TNFalpha secretion (Suzuki et al., 2006; Park et al., 2007) via alpha7-dependent activation of JNK and MAPK pathways.

Related Edges 3

• a(CHEBI:nicotine) regulates act(p(HGNC:TNF))
• complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK))
• complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade")

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