p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")

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PubMed:26631930

In a cellular model of tauopathy, cells expressing the ΔK280 repeat-domain-mutant tau show tau aggregation that depends on the stepwise proteolysis of the N‑terminal domain by a thrombin-like protease and of the C‑terminal domain by cathepsin L, generating a fragment (F3) that leads to robust aggregation in cell and animal models

Related Edges 3

• p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360"))
• p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360"))
• p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates")

MeSH

Tauopathies

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