p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081)))

PubMed:22122372

In the amyloidogenic pathway, APP is primarily processed by beta-secretase at the first residue or at the 11th residue (so called beta’ site) of the Abeta peptide sequence (Fig. 1), shedding sAPPbeta and generating a membrane associated C-terminal fragment consisting of 99 amino acids (C99) (Sarah and Robert 2007)

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.