p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081)))

PubMed:22122372

Abeta generation is initiated by beta-cleavage at the ectodomain of APP, resulting in the generation of an sAPP-beta domain and the membrane associated APP C-terminal fragment C99. The putative beta-secretase, beta-site APP cleaving enzyme 1 (BACE1), was first identified and characterized in 1999 (Sinha et al. 1999; Vassar et al. 1999; Yan et al. 1999; Hussain et al. 2000; Lin et al. 2000).

Confidence

High

MeSH

Neurons

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