a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7))

PubMed:19126755

The Abeta1-42 peptide is one of the breakdown products of the proteolytic cleavage of the amyloid precursor protein by beta- and gamma-secretases. In biopsy samples of human brain tissue obtained from AD patients and in ectopic systems overexpressing either alpha7 nAChRs or APP, Abeta1-42 coimmunoprecipitates with alpha7 nAChRs (490). The Abeta1-42 peptide also displaces binding of [3H]MLA from alpha7 nAChRs in cerebral cortical and hippocampal synaptosomes (490).

Related Edges 3

• a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7))
• p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42")
• p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42")

MeSH

Brain

MeSH

Alzheimer Disease

Text Location

Review

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