act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling")

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PubMed:19293145

Calcium signaling pathways are involved both in the toxic action of Abeta and in the protection against that toxicity offered by nicotinic ligands. Given that alpha7 homomeric nAChRs are much more permeable to calcium ions than are most other nAChRs (Bertrand et al., 1993), it is to be expected that nicotinic neuroprotection mediated by nAChRs, notably alpha7, would depend upon the activation of calcium signaling pathways. ABT-418 is a nicotinic agonist that protects primary rat cortical neurons from glutamate toxicity through its activation of alpha7 nAChRs, and this is blocked when calcium is removed from the extracellular medium (Donnelly-Roberts et al., 1996).

Related Edges 9

• act(a(CHEBI:"amyloid-beta")) association bp(GO:"calcium-mediated signaling")
• a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole"))
• a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7))
• bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta"))
• bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection)
• bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7))
• bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling")
• act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport")
• act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)"))

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