act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))

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PubMed:29311797

Cdc37 is also required for the stable folding of protein kinases in coordination with Hsp90 (Calderwood, 2015). Many of these kinases are known to phosphorylate tau at sites associated with AD, such as GSK3β and MAPK13 (Taipale et al., 2012; Jin et al., 2016).

Related Edges 3

• complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B)
• complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13)
• act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))

MeSH

Cerebral Cortex

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