path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE)

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PubMed:19293145

The apolipoprotein E type 4 allele (APOE-epsilon4) encodes the APOE lipoprotein, which through its lipid transport function plays a role in lipid metabolism. APOE-epsilon4 has been found to be a major risk factor for late familial or sporadic AD, with a strong gene-dosage effect such that the number of APOE-epsilon4 alleles correlated positively with the risk of developing AD and the age of onset (Corder et al., 1993).

Related Edges 4

• bp(GO:"lipid metabolic process") association p(HGNC:APOE)
• p(HGNC:APOE) association bp(GO:"lipid metabolic process")
• g(HGNC:APOE) increases p(HGNC:APOE)
• g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease")

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