a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR"))

PubMed:19126755

Finally, bupropion (16, 294, 433) and UCI-30002 (514) are examples of synthetic compounds that act as noncompetitive inhibitors of different nAChRs, including those made up of the subunits alpha7, alpha4beta2, or alpha3beta4. Both compounds effectively decrease nicotine self-administration in rats (280, 514). Bupropion is presently approved as an adjunct therapy for smoking cessation.

Related Edges 7

• a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7))
• a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
• a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR"))
• a(CHEBI:bupropion) association path(MESH:"Smoking Cessation")
• a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7))
• a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR"))
• path(MESH:"Smoking Cessation") association a(CHEBI:bupropion)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.