p(HGNC:CDC37) decreases deg(p(HGNC:MAPT))

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PubMed:21367866

Previous work showed that Hsp90 inhibition with 17-AAG reduced phospho-tau levels in vivo (16, 23). We speculated that Cdc37 might modulate Hsp90 inhibitor efficacy for phosphotau. M17 cells were transfected with Cdc37 siRNA and then treated with 1 μM 17-AAG for 24 h. Indeed, reducing Cdc37 synergized with Hsp90 inhibition to reduce tau levels more potently than either condition alone (Fig. 6A).

Related Edges 3

• a(CHEBI:tanespimycin) decreases act(p(SFAM:"HSP90 Family"))
• deg(p(HGNC:MAPT)) negativeCorrelation act(p(SFAM:"HSP90 Family"))
• act(p(SFAM:"HSP90 Family")) negativeCorrelation deg(p(HGNC:MAPT))

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