act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K))

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PubMed:19293145

For instance, over-expressing PI3K in Drosophila melanogaster neurons in situ results in an increase in functional synapses as well as synaptic sprouting (Martín-Pen˜ a et al., 2006). Thus it is possible that nicotine’s activation of the PI3K pathway results in increased synaptic stability, and it would be of interest to explore this further in vertebrates. Thus, the evidence suggests that activation of nAChRs activates the PI3K/AKT pathway to favor antiapoptotic pathways and possibly induce synaptogenesis.

Related Edges 3

• a(CHEBI:nicotine) increases act(p(FPLX:PI3K))
• p(FPLX:PI3K) increases act(a(MESH:Synapses))
• act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process")

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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