p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates")

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PubMed:14556719

They have demonstrated that AD can be caused by mutations in the APP gene, either in the vicinity of the secretase cleavage sites, causing abnormal APP processing, or in the sequence coding for Abeta, giving rise to a peptide that is more likely to self-aggregate

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