p(HGNC:MAPT, var("p.Pro301Leu")) increases bp(GO:memory)

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PubMed:26631930

Remarkably, in two regulatable transgenic mouse models expressing human tau with the P301L mutation (rTg4510) or expressing the repeat domain of tau with the ΔK280 mutation, switching off tau expression improved memory impairment even though NFTs remained, clearly showing that tau aggregates are not sufficient for neurodegeneration and the cognitive effects that are typically observed in these models

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• p(HGNC:MAPT, var("p.Lys280del")) increases bp(GO:memory)

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