p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ac, Lys, 46))

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PubMed:22926167

Because Pin1 has at least 4 major isovariants in addition to the native polypeptide, this means that Pin1 has 4 (possibly more) posttranslational modifications including phosphorylation at 3 sites (Ser16 and Ser65/Ser71), N-acetylation (amino-terminus and Lys46) and oxidation (Met130 and 146). In all experimental conditions, including tau-overexpressing cells, tau transgenic mice and AD brains, global levels of Pin1 posttranslational modifications were decreased compared with control conditions.

Related Edges 7

• p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71))
• p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 16))
• p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 65))
• p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT)

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