a(CHEBI:"D-ribose") increases p(HBP:"Tau aggregates")

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PubMed:19517062

Tau is rapidly glycated in the presence of D-ribose, resulting in oligomerization and polymerization with Glycated derivatives appearing after 24 h. Advanced glycation end-products (AGEs) were formed during initial stages of glycation. Thioflavin T-positive (ThT-positive) aggregations (day 4) indicated the globular-like features. Atomic force microscopy revealed that the surface morphology of ribosylated Tau40 was globular-like.

Related Edges 2

• a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation))
• p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product")

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